![]() Generic Name Protamine sulfate DrugBank Accession Number DB09141 Background. ![]() Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Protamine sulfate is a blood factor used when the reversal of the anticoagulant effect of heparin is necessary and for the treatment of heparin overdose. The term 'vitamin K antagonist' is a misnomer, as the drugs do not directly antagonise the action of vitamin K in the pharmacological sense, but rather the recycling of vitamin K. Portions of this document last updated: May 01, 2023Ĭopyright: © Merative US L.P. Keep from freezing.ĭo not keep outdated medicine or medicine no longer needed. Factors II, VII, IX, and X which are all important for the intrinsic and common pathways of coagulation. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Vitamin K is a fat-soluble vitamin necessary for synthesis of coagulation factors involved in the coagulation cascade. Tell your doctor about any doses you miss. These substances help your blood to thicken and stop. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. USES: Vitamin K is used to treat and prevent low levels of certain substances (blood clotting factors) that your body naturally produces. If you miss a dose of this medicine, take it as soon as possible. ![]() The dose may be repeated after six to eight hours, if needed. Vitamin K helps to treat and prevent unusual bleeding by increasing the bodys production of blood clotting factors. The usual dose is 0.5 to 1 mg, injected into a muscle or under the skin, right after delivery. The dose may be repeated, if needed.Īdults and teenagers-The usual dose is 2.5 to 25 mg, rarely up to 50 mg, injected under the skin. For menadiolįor problems with blood clotting or increased bleeding, or for dietary supplementation:Īdults and children-The usual dose is 5 to 10 milligrams (mg) a day.Īdults and teenagers-The usual dose is 5 to 15 mg, injected into a muscle or under the skin, one or two times a day.Ĭhildren-The usual dose is 5 to 10 mg, injected into a muscle or under the skin, one or two times a day.įor problems with blood clotting or increased bleeding:Īdults and teenagers-The usual dose is 2.5 to 25 milligrams (mg), rarely up to 50 mg. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. However, this does not necessarily mean no interactions exist. The amount of medicine that you take depends on the strength of the medicine. Vitamin K antagonists (VKAs) are still used to prevent ischemic stroke (IS) in patients with atrial fibrillation and remain the only recommended oral treatment for patients with mechanical heart valves. No interactions were found between aspirin and Vitamin K. If your dose is different, do not change it unless your doctor tells you to do so. The following information includes only the average doses of these medicines. ![]() Follow your doctor's orders or the directions on the label. Although antidotes against anticoagulant treatment are widely available, our analysis shows that in only a very small number of patients a direct, or slow-acting antidote to reverse the anticoagulant effect was used.The dose medicines in this class will be different for different patients. Vitamin K was more frequently given in case of a higher international normalized ratio value. Antidotes were statistically significantly more frequently given in Canada as compared to other participating countries. The use of antidotes was comparable for initial and long-term treatment. Vitamin K was given to 23 (1.2%) patients, one (0.05%) patient received protamin sulfate and seven (0.4%) patients received fresh frozen plasma. Of the patients with at least one major hemorrhage, 19 (41.3%) received an antidote. If an immediate effect is required, unfractionated or low molecular weight heparin must be given concomitantly. Some form of antidote was given to 26 (14.4%) patients with a hemorrhage. The oral anticoagulants warfarin sodium, acenocoumarol and phenindione, antagonise the effects of vitamin K, and take at least 48 to 72 hours for the anticoagulant effect to develop fully warfarin sodium is the drug of choice. We investigated 1877 patients treated for venous thromboembolism included in three large clinical trials, of which 181 (9.6%) had a total of 225 adjudicated bleeding episodes 46 hemorrhages being designated as major. Interestingly, it is unknown how often the use of an antidote is necessary in clinical practice. Several new anticoagulants have been developed that are likely to have some risk of bleeding complications, for which no specific antidotes are available. When a bleeding complication occurs during therapy with heparin or vitamin K antagonists, there is an option to give a specific antidote.
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